Stress and burnout are universal problems affecting human beings. Unfortunately, physicians are one of the top professionals recently encountering this. Signs of emotional exhaustion, lack of motivation at work, and not feeling connected to a broader purpose are detrimental to a radiologist’s life and the healthcare system. In this chapter, we review essential contributing factors causing stress and burnout in radiologists, tools to assess overall physician well-being, and strategies to improve physician wellness at an individual and organizational level.