Polygraphic investigations provide a correlation between a behavioral manifestation and a variable set of physiologic parameters. In the study of epilepsy, polygraphic recordings can be essential to identify and describe the occurrence and characteristics of changes occurring in various physiologic functions in concomitance with epileptic abnormalities as documented in the electroencephalogram (EEG) and clarify their temporal correlation with the EEG events. In particular, polygraphy can be essential to define the various motor manifestations that characterize different types of epileptic seizures and syndromes. In addition, polygraphic studies can be crucial to establish and verify diagnostic hypotheses and to elucidate the pathophysiology of the various epileptic motor phenomena. In this chapter, we provide an overview of the polygraphic features of various epileptic motor manifestations that can be specific features of different epileptic syndromes, and we illustrate how polygraphic studies can contribute to the comprehension of their pathophysiological mechanisms.