This chapter examines a contemporary notion of organism useful for architectural design. The new definition of organism and organicity, have little to do with the naturalistic matrices used through the imitation of nature. They rather express the aspiration, often disappointed but always persistently sought, for a unifying synthesis, which runs through even the most critical phases of architectural history. The idea of organic solidarity between the components that determine the appearance of the built form still continues in the center of modernity, like in much of modern Mediterranean architecture, using load-bearing and enclosing forms, organic binding construction, space, language in an aesthetic synthesis. The problem of designing organically, following the formative process of built reality, clashes today with design techniques undergoing a progressive phenomenon of abstraction. The media and manipulated interpretation of the built form is superimposed on the direct and natural perception of reality. Examples of design practice are proposed.