This chapter examines the application of agile methodologies to R&D, highlighting their potential to enhance flexibility, accelerate innovation, and improve project outcomes. While agile principles, such as iterative sprints and continuous feedback, have revolutionized product development, integrating these practices into research requires careful adaptation due to the unpredictable and exploratory nature of R&D. The chapter explores how frameworks like Lean Start-up, Six Sigma, Stage-Gate, and the Double Diamond can be tailored to fit your R&D needs and objectives, offering a blend of structure and adaptability. Practical advice to project managers is provided on breaking down research goals, managing resources efficiently, and fostering collaboration between researchers, engineers, and developers. Importantly, the chapter emphasizes the human element, underscoring the need to cultivate creativity, collaboration, and trust within R&D teams.