This paper examines the transformative potential of digitalization for oil and gas processing facilities. It analyzes both the opportunities (improved process efficiency, safety enhancement, cost reduction, and promoting sustainability) and challenges (legacy infrastructure, cybersecurity risks and threads, workforce skills gaps and system safety concerns) associated with successful implementation. Digitalization offers significant opportunities for oil and gas processing facilities to enhance process efficiency, improve safety, reduce operational costs, and drive sustainability initiatives. However, companies must overcome the challenges outlined above to fully realize these benefits. A holistic digitization strategy that prioritizes upskilling, strategic partnerships, change management, and a focus on long-term outcomes is crucial. The research leverages a comprehensive literature review and analysis of key technologies (Big Data, Industrial Internet of Things “IIoT” and AI/ML) to build a foundation for a people-centric strategic framework. This framework emphasizes the interconnectedness of people, technology, and process for successful digital transformation, highlighting the importance of upskilling, strategic partnerships, change management, and a long-term outlook. The paper details actionable insights for oil and gas companies seeking to navigate digital transformation within their processing facilities. By adopting a holistic approach that prioritizes people, companies can unlock the full potential of digitalization and achieve long-term success in today’s technology-driven landscape.