Human beings are social animals. Social behavior and attachments serve wide-ranging functions, the most basic of which is the survival of our species. Regarding mental health, human beings who are securely attached to others can self-regulate and cope with stressful situations in more adaptive ways. As expected, people get extremely depressed or may not even survive solitary confinement. Attachment patterns start developing from the very beginning of life. Reciprocal interactions between a mother and her baby foster the development of secure attachment patterns. A child who grows up with secure attachments is better equipped to form healthy relationships and cope with the inherent strains of adulthood. However, it’s the quality of these mother-baby interactions within critical periods of infant development that leads to secure attachment. These interactions can be significantly impacted by the peculiarities in neurocognitive and social functions seen in individuals with NDD. This chapter starts with a basic description of attachment theory and the types of attachment patterns seen in humans. Next, I will discuss how this early developmental process can be adversely affected by the presence of NDD in mothers. Research data on the subject is quite limited, but the author presents clinical anecdotes from working with mothers as a perinatal psychiatrist.