Purpose: This study investigates how entrepreneurial strategies foster sustainable practices in India’s circular supply chains, addressing challenges such as fragmented supply networks, reliance on informal sectors, and regulatory gaps. It bridges the research gap in understanding context-specific strategies for circular economy adoption. Design/Methodology/Approach: This study employs qualitative research methods, including a systematic literature review of peer-reviewed articles (2015–2023) and thematic analysis of policy documents and industry reports. By synthesizing theoretical frameworks and practical examples, the research explores how Indian entrepreneurs integrate circular economy principles into supply chains. Data triangulation ensures alignment with entrepreneurship, sustainability, and Sustainable Development Goals (SDGs). Findings: Indian entrepreneurs capitalize product innovation exemplified by Banyan Nation’s plastic recycling, collaborative partnerships such as Goonj’s waste reuse networks, and digital tools including blockchain for traceability to align with Sustainable Development Goals 9 and 12. Key barriers include inconsistent policy enforcement, consumer price sensitivity, and infrastructural deficits in waste management. Practical Implications: Policymakers should harmonize regulations such as tax incentives for circular economy research and development and invest in waste infrastructure. Entrepreneurs must prioritize affordability-optimized circular models and stakeholder education. Originality/Value: This study provides a framework for integrating circular economy principles into India’s supply chains, emphasizing the role of informal sectors, digital innovation, and Sustainable Development Goal-aligned entrepreneurship.