In modern supply chain management systems and practices, human entrepreneurship is the fulcrum with respect to fostering and activating innovation, attaining efficiency, and therefore leading toward the path of sustainability. This book chapter highlights the interplay of human entrepreneurship and supply chain management, exploring myriad themes, case studies, theoretical frameworks, and findings from a review of the literature. It exemplifies how entrepreneurial thinking caps and implementation impact the dynamics of the supply chain, from acquisition and possession to distribution and stockpiling. It also delves into the impact of entrepreneurial leadership skills on resilience, acrobatic agility, and alteration/adjustment to the volatile market scenario. This successful integration of human-centric entrepreneurial strategies bolsters and optimizes the supply chain performance and competitiveness. The review concludes with the main legal provisions that support sustainable human entrepreneurship, policy implications, and future directions in this ever-evolving human entrepreneurship shaping and striving with the foot on the pedal toward creative and sustainable supply chain strategies.