In response to the persistence of mental illness stigma, scholars have begun to focus on the cultural contexts in which stigma is embedded with the understanding that changing culturally created meanings of mental illness is key to collectively defining people with mental illness as valued community members. With respect to the cultural context of higher education, this chapter aims to serve two audiences who do not talk to each other enough: (1) mental illness scholars and practitioners and (2) higher education decision-makers. In the interest of scholars and practitioners, we discuss the social origins of mental illness stigma, consider the ways meanings surrounding mental illness are transmitted to and uniquely represented in the context of higher education, and examine the implications of stigmatization for higher education community members. In the interest of higher education decision-makers, we offer a case study illustrating a campus culture of mental illness stigma and review actions taken to address the sources of this stigma. We end the chapter by considering evidence pointing to contexts in which persons with mental illness thrive and discuss their applicability to the context of higher education in general.