Trauma simulation is a critical component in the training of the healthcare team, including physicians, first responders nurses, and medical students. Simulation plays a pivotal role in enhancing skills, knowledge, and communication. This type of simulation is often conducted through mass casualty scenarios, where multiple scenes are designed to achieve diverse learning objectives. While the primary focus of a simulation center might be on enhancing procedural skills, trauma training requires a more nuanced approach. The planning stage must address various considerations, from identifying specific needs to aligning with strategic goals and vision. Designing a center dedicated to trauma simulation involves navigating these complexities to ensure the facility is equipped to meet the diverse demands of trauma education. This chapter provides a comprehensive guide to designing a simulation center that effectively supports trauma training, whether in an academic setting or a hospital-based environment. Drawing on years of trial and error and firsthand experiences, it offers valuable insights into the design and operational considerations essential for creating a center that meets the evolving needs of trauma education.