The search for missing persons is a complex and multifaceted process requiring both traditional methods and innovative technological solutions. This chapter explores cutting-edge methodologies such as geographic profiling, geographic information systems (GIS), drones, ground-penetrating radar (GPR), and remote sensing (RS). These technologies enhance efficiency by narrowing search areas, predicting likely locations, and leveraging spatial data for real-time decision-making. Key approaches include geolocation techniques, predictive modeling, and advanced geospatial analyses like locus operandi, tailored specifically for missing person cases. By integrating these tools with traditional search efforts, search and rescue operations can improve their success rates, particularly during the critical “golden hours.” Emphasis is placed on interdisciplinary collaboration, ethical considerations, and the necessity for specialized training to maximize the potential of these innovations in forensic investigations.