It is widely recognized that religious cultural heritage is one of the founding elements of landscape. Religious buildings and monuments belong not only to the community of believers who use them, but to the history and culture of people as a whole and pilgrimage sites and religious routes very clearly express this characteristic. The study of landscapes in relation to the ongoing transformations of sacred places and the increasingly frequent phenomena of the abandonment of churches and monasteries offers an interesting analysis of the intricate relationships between religious practices, like the pilgrimages, and physical space. The article aims to analyze the relationship between religious cultural heritage and landscape starting from examples focused on the reuse of disused or underused religious heritage connected to pilgrimage practices or religious routes. The discussion is developed through selected case studies from Italy and Germany: the Italian case studies focus on the so-called Miglio Sacro, a mile-long religious route through the hilly landscape typical of Naples in Italy. The German examples are representative of a spatial network of religious buildings connected to important pilgrimage sites. Comparing different geographical regions can be useful to show differences and similarities between their religious cultural heritage, architectural characters, relationship with communities, and management methods.