The healthcareHealthcare sector has increasingly demonstrated its attention and adaptability to ESGESG (Environment, Social, Governance) challenges. Hospital infrastructures, where healthcareHealthcare services are provided, play a leading role in the transition towards ESGESG-driven models. Through an exploration of the existing scientific and grey literature, and a case study investigation, the study aims at scrutinizing financingFinancing models involving the private sector, to support public healthcareHealthcare organizations to enhance the ESGESG performancePerformance of hospital infrastructures. The analysis conducted has led to the identification of various financingFinancing schemes to improve ESGESG performancePerformance in hospital environments such as Public–Private Partnership, Energy PerformancePerformance Contracts (EPC), Green and Social Impact Project Bonds. The pivotal role of ESGESG strategies enables the strengthening of hospital infrastructures for the improvement of societies and the reduction of environmental impacts. The chapter emphasizes the critical role of sustainable healthcareHealthcare investments within the ESGESG framework, particularly in relation to hospital infrastructure. By exploring various financial models and instruments designed to enhance ESGESG performancePerformance, the analysis highlights the opportunity for healthcareHealthcare institutions to collaborate with the private sector to renovate the hospital building stock while achieving meaningful environmental, social, and financial outcomes.