Pampean lakes have been the subject of archaeological and, particularly, bioanthropological investigations since the mid-twentieth century. Topics such as subsistence strategies, mobility, chronology of occupations, technology, and forms of burial, have been addressed bioanthropologically and bioarchaeologically. Within a broader chronological framework, Pampean lakes can be thought of as territories that nucleated human interest and occupation throughout the Holocene, albeit with different intensity in the occupation pulses and with their own characteristics, some of which were shared between the different areas. In this chapter, main contributions from bioanthropology and bioarchaeology are reviewed, for the entire region, focusing on the dynamics of human occupation of the southern coast of Laguna Mar Chiquita, in the province of Córdoba.