I based this text on extracts from previous publications and others not really published (speeches, conferences, including the one in the Humanism in Surgery Symposium) as well as on what I wrote for the opening text of my website josepocas.com , devoted to the topic: Medicine: Culture, Science and Humanism. It deals with what I consider to be the core of the exercise of Clinical Medicine and its ethical foundations, a result from what I have been observing and reflecting over more than 40 years of professional practice, and also on what I have consulted, read and debated with colleagues and patients. I believe that the progress of technology, which is unstoppable and increasingly vertiginous, should motivate everyone (doctors and other health professionals, patients, citizens, teachers, ethicists, philosophers, engineers, lawyers, researchers, trade associations and political decision-makers) to reflect deeply on the personal and social desired response to illness of patients and on the global health problems. We must focus essentially on the values of humanisation and respect for professional deontology, knowing how to suitably frame technological innovations to simultaneously, not violate those basic principles, but make the exercise of medical activity more assertive concerning to prophylaxis, diagnosis and treatment of the diseases that affect patients, as only in this way can the medical act and the doctor-patient relationship be materialised respecting the ancient Hippocratic tradition, however adapted to current times.