Mosquito-borne diseases significantly burden human health across the world. Their eradication remains challenging, necessitating a comprehensive understanding of the intricate interactions between the host, the mosquito vector, and the environment. The complex interplay between them influences human susceptibility to mosquitoes. Identifying the specific microbial factors that affect mosquito attraction and the underlying molecular mechanisms involved will pave the way for novel interventions targeting microbiota-vector interactions. Two scientific databases (Public Library of Medicine and Google Scholar) were searched, with the year of search specified as 2018–2023. Thirteen thousand nine hundred twenty-three search results were returned from PubMed and Google Scholar databases. Articles were pre-screened using their title and abstracts. Only five articles on the interconnection of differential attraction in humans and the contribution of the environment were downloaded for this review. This review provided insights into why mosquitoes showed variation in host preference, both between and within species, due to variations in the volatile compounds (VOCs) like CO2, lactic acid, and terpenes produced by hosts. It also highlights the role of the environment in the proliferation of mosquitoes due to favorable climatic conditions for their breeding and contributory factors for the human skin microbiota based on the mode of delivery, hygiene routine, etc. The VOCs identified should be used to develop noninvasive diagnostic techniques to reduce the burden of malaria.