The depiction of pregnancy and the beginning of life in art has mirrored humanity’s evolving understanding of reproduction throughout history. From the earliest cave paintings celebrating fertility to Renaissance masterpieces that integrated scientific exploration, art has consistently reflected society’s fascination with birth. In ancient Egypt, the concept of the beginning of life was closely linked to cosmology, with deities like Isis, Osiris, and Tawaret symbolizing fertility, regeneration, and pregnancy. The Egyptians saw the creation of life as interconnected with the cosmos, and their art often depicted the birth of Horus as a divine process, blending embryology and cosmology. This reverence for fertility and birth influenced their mythology and art, intertwining with religious and symbolic beliefs. During the Renaissance, artists like Leonardo da Vinci further transformed our understanding of human anatomy, merging art and science to explore the complexities of pregnancy. In the modern era, art continues to engage with technological advancements such as ectogenesis, with artists exploring the ethical and societal implications of creating life outside the womb. This chapter traces these historical milestones, examining how artistic representations of pregnancy and birth have influenced and reflected the evolving discussions on human reproduction, from ancient Egypt to contemporary scientific innovations.