This chapter explains the concept of responsible innovation and shows how it may be applied to concrete innovation practices. It starts by discussing the notion of responsibility and its different meanings, including forward-looking and backward-looking responsibility. It then follows a fictional startup, ‘Chatter,’ in its attempts to apply responsible innovation practices. It shows how Chatter uses scenario exercises to anticipate ethical impacts, how it uses value sensitive design approaches to embed values in design, and how it uses ethical checklists to evaluate ethical impacts of the products it launched.