The chapter examines the European Global Health Strategy (EU GHS), emphasizing its evolution amidst the COVID-19 pandemic and its positioning as a cornerstone of EU external policy. It argues that the pandemic catalyzed global health’s elevation to “high politics,” aligning it with EU priorities such as security and sustainability. Despite health remaining a member-state competence, the strategy bridges internal and external policy through a rights-based approach, focusing on universal health coverage, health threats prevention, and the One Health paradigm. The strategy underscores partnerships, particularly with the African Union (AU), emphasizing co-responsibility, mutual investments, and multilateral governance. The EU GHS also highlights trade policy’s critical role in securing global health resilience. However, implementation faces barriers like trade wars, political fragmentation, and the lack of legal mandates. Against this background, a new monitoring mechanism is supposed to ensure accountability, while challenges such as lack of action and geopolitical shifts test the strategy’s adaptability.