The immune system protects the body from invasive foreign organisms and substances. In immunocompromised disorders, the immune system is unable to provide protection against microbial invasions, and as such may predispose patients to severe and potentially life-threatening infections (Amrol, Immunodeficiency. American Academy of PediatricsItasca, IL eBooks, 2018). Inborn errors of immunity are inherited conditions affecting the function of the immune system which include but are not limited to B-cell, T-cell, phagocytic functions, or complement system whereas secondary immunodeficiency is immunodeficiency acquired due to underlying conditions or medications (McCusker et al., Allergy Asthma Clin Immunol, 14, S2, 2018). Children with immunocompromised disorders require close monitoring in the school setting for outbreaks or signs of infection, given the potential for severe and life-threatening complications.