The provision of safe, resilient and smart mobility services for both passengers and goods is a key priority for the EU transport sector. Even though passenger and freight transport systems share space, infrastructure and challenges, the current governance and regulatory systems deal with them in silos. This paper aims to provide an overview of the current status of passenger and freight transportation, focusing on the specific characteristics, limitations and barriers that prevent the collaboration, as well as the interdependencies and the opportunities for synergies and integrated transport schemes. The latest research related to the adoption of effective approaches enabling integration of passenger and freight transport is also presented, towards interoperability in multimodal transport ecosystem. The concept and results from the EU-funded research project DELPHI are discussed, highlighting the role of regulatory/governance systems and data sharing schemes in the integrated passenger and freight transport. The DELPHI case studies and demonstrators are also presented, along with their expected impact on current mobility and logistics services, and how they can be sustainably implemented, replicated and widely adopted by stakeholders.