Distraction in healthcare manifests as a mismatch between capabilities of individuals, teams, and organizations and the quality of the work that they actually achieve. Distractions can come from the clinical environment as well as from within our own minds. Mindful practice refers to the capacity to regulate one’s attention, focus on what is most important, and bring wisdom to clinical practice through self-awareness, situation and emotional awareness within teams, and structures, processes, and workplace climate of healthcare organizations. Fundamental qualities of mindful practitioners, teams, and organizations include attentive observation, critical curiosity, beginner’s mind, and presence. These qualities are associated with improved quality of care and human relationships (between patients and clinicians, among clinicians, and within organizations), and sustainability of the healthcare workforce. In this chapter, I propose ways of optimizing the healthcare work environment through contemplative practices, deep listening, team training, and organizational redesign to address those distractions that come from the workplace and those that emanate from one’s own mind.