This chapter explores the multifaceted impact of disasters on pediatric populations, examining the immediate and long-term effects on children’s physical, emotional, and psychological well-being. It delves into the disruption of healthcare services due to disasters, the scarcity of pediatric-specific resources, and examines their unique effects on children. The chapter outlines the phases of disaster management, emphasizing the importance of tailoring systematic approaches and response strategies informed by past experiences. It explores key metrics like crude mortality rates and the environmental factors influencing pediatric morbidity and mortality during emergencies. The discussion extends to leading causes of humanitarian crises and evaluates the effectiveness of World Health Organization (WHO) emergency relief measures. Additionally, the chapter highlights the roles of national and international organizations in providing critical support during humanitarian emergencies, to enhance resilience and recovery in pediatric disaster survivors, underscoring the need for coordinated efforts to address the specific needs of children in disaster scenarios.