Suicide occurs in all regions resulting in deleterious emotional, physical, and economic impacts on families and loved ones, community members, and communities around the world. Stress, health issues, and depression are often precursors to suicide. While one’s occupation can be a protective factor by providing purpose and a place of belonging, it can also be a significant stressor in people’s lives. Occupational suicide has become an increasingly prevalent and pressing concern for employers across the globe. This chapter explores the phenomenon of occupational suicide throughout the United States, Europe, Asia, and the rest of the world including the prevalence of occupational suicide, risk factors for occupational suicide, differences in professions, and sociocultural factors.