The incorporation of nanomaterials in advanced material systems has revolutionized various industries, and the construction, oil, and gas sectors are no exception. This chapter provides a comprehensive overview of the multifaceted applications of nanoclays in these industries, highlighting their role in enhancing material properties, improving structural as well as functional performance, and addressing environmental challenges. Environmental sustainability is a growing concern in all industries, and nanoclays offer promising solutions. This chapter explores how nanoclays can be employed in remediation efforts to mitigate soil and groundwater contamination, as well as in the development of eco-friendly drilling fluids and construction materials. Lastly, the chapter addresses challenges and prospects of nanoclay applications in construction, oil, and gas industries, emphasizing the need for continued research and development to unlock their full potential. The integration of nanoclays into these sectors has the potential to revolutionize their practices, making them more efficient, cost-effective, and environmentally friendly. Thus, a comprehensive exploration of the diverse and promising applications of nanoclays in these niches, underlining their transformative potential and their role in shaping a more sustainable future for these vital sectors, is discussed herewith.