The Anthropocene proposal has been widely debated in the past 20 years across the whole academic spectrum. It forces actors from different disciplines to leave comforting long-established cultures of knowledge production to favor an active negotiation process about anthropogenic aspects beyond disciplinary boundaries. Besides these negotiation processes, this chapter examines the standing of the AWG outside the geoscientific community and the potentials and limits that humanities and social science scholars ascribe to the geoscientific Anthropocene concept. The findings are based on 25 expert interviews with central actors of the Anthropocene debate and a comprehensive literature review (2000–2020). Particular emphasis is placed on the provocative potential that the geoscientific Anthropocene concept represents for other disciplines because it illustrates the conflicts that structure Anthropocene discourses at disciplinary interfaces. These conflicts are primarily based on disciplinary methodological differences, but to a considerable extent, they are also rooted in a competition for epistemic leadership (interpretive sovereignty). Using selected thematic key topics, this chapter exposes the structure, course, and consequences of transdisciplinary negotiation processes. On this basis, it highlights the potential of the Anthropocene as a possible academic game-changer leading to a new form of scientific collaboration. This chapter highlights the downside of conflicting Anthropocene discourses and argues for an even broader interdisciplinarity of Anthropocene research.