Over time, a surfeit of pesticide usage for plant disease management has evoked various environmental concerns. At the same time, this practice has led to pathogens developing resistance to the most used pesticides over years. The plant growth-promoting rhizobacteria (PGPR) constitute a heterogeneous group of microorganisms that colonize the rhizosphere. These microorganisms possess a multitude of beneficial properties like plant disease control, phosphate solubilization, quorum sensing, and other features. Besides this, the PGPR applied to plants is also capable of assuaging abiotic stress and improving the endurance of plants to different kinds of abiotic stresses like drought and salinity. The most popularly used PGPR include different species of Bacillus and Pseudomonas well known for their antagonistic activity against plant-infecting pathogens. Besides this members of the genera Azotobacter, Allorhizobium, Serratia, Streptomyces, Azorhizobium, etc., have also been well exploited. A wide range of PGPRs has been commercially formulated as biofertilizer products. Mechanisms used by PGPR organisms against plant pathogens involve the production of antibiotics, siderophores, hydrogen cyanide, and lytic enzymes. PGPR also helps stimulate the defense mechanism of plant host by the generation of induced systemic resistance and systemic acquired resistance in plant system. The beneficial effects of PGPR for viral disease management have also been well documented. An ideal PGPR used against plant infection should be an effective rhizosphere colonizer, exhibit broad-spectrum nature, and display plant growth-promoting activities. Moreover, the multiplication ability of PGPR effective in lab needs to be tested and compared under field conditions prior to large-scale production.