In different conditions of changing environmental parameters, plants undergo several biotic and abiotic stresses. This may hamper the productivity and functionality of the plant and its overall systemic growth. These stress conditions, directly or indirectly, affect different domains of plant systems. They trigger a wide range of changes in the plant physiological system that affects its growth in different realms of development. The morphological, biochemical, and molecular changes are major stress determinants and regulators, which get modified according to the oxidative, salinity, drought, temperature, and other environmental triggers. There are various plant resistance mechanisms by which the plant copes with the ongoing stressors, which may include molecular modifications, phenotypic flexibility, root growth modifications, and genetic expression modification on subcellular levels. Signaling pathways associated with corresponding stressors generate an adaptive response at subsequent molecular levels, playing an integral role in stress detection, regulation, and management by generating adequate morphological and biochemical responses. The chapter envisions to give an insight on the stress modulation undertaken by plant systems in unfavorable physiological conditions.