The environment is severely impacted by anthropogenic and technological activities in the twenty-first century, particularly in agriculture and allied sectors. Nitrile-based products, such as nylon, nitrile butadiene rubber, and nitrile-containing pesticides, cause environmental pollution due to their gradual degradation. Nitrile contamination increases due to industrial effluents and overuse of nitrile pesticides. Plants release nitrile in the crop ecosystem through root exudates, polluting the crop’s micro-climate. These nitrile compounds persist in the crop environment and interact with soil properties, affecting crop productivity. If they get into groundwater and the food chain, they pose a greater threat to human health and the ecosystem. Bioremediation, specifically with soil-beneficial bacteria, has shown potential for mitigating nitrile pollution. However, adequate research is lacking on the effects of these bacteria on soil and plant habitats. Nitrilase-active plant growth-promoting rhizobacteria (PGPR) have drawn interest as a potential remedy for nitrile pollution in croplands.