Environmental stresses are a persistent issue for plants. As a result of anthropogenic activity, metals were built on the surface of the soil. The term “heavy metals” refers to metals having densities higher than 5 g cm−3. One of the biggest threats to the long-term viability of the agroecosystem is heavy metal pollution, which poses a risk to both the ecosystem and human well-being. One of the most economical and environmentally acceptable methods of phytoremediation is to utilize rhizospheric or endophytic microorganisms, which have properties that promote metal resistance and plant development. The host plant’s ability to cope with such a hazardous environment can be altered by plant growth-promoting rhizobacteria (PGPR). PGPR, directly and indirectly, promote heavy metal stress tolerance by enhancing both water and mineral nutrient uptake, boosting shoot biomass, and altering root architecture. It also reduces oxidative stress by increasing the antioxidant enzymes activity and lowering the buildup of free radicals and the level of lipid peroxidation. As a result, the HM-exposed plants ROS homeostasis may be aided by the rhizobacterial-mediated antioxidative system. They can be crucial in the accumulation and distribution of HMs to aboveground plant components by interplay with plant transporters. PGPR can chelate and sequestrate the HMs and act as a physical barrier to the entry of HMs into plant systems. This chapter would pay for exploiting the new insights of PGPR in the phytoremediation of HMs.