Purpose: This research provides a case study applying Lean Six Sigma (LSS) in a higher educational institution to design and improve lab safety within an institution’s experiential-based engineering technology program. In an academic environment, mistakes are inevitable. However, in a laboratory, if left to chance, these mistakes can turn disastrous. This project aims to improve the engineering lab safety processes within the new engineering technology program, through assorted trainings and accident mitigation techniques. Study Design/Methodology/Approach: The Lean Six Sigma DMAIC (Define-Measure-Analyze-Improve-Control) methodology was applied within an undergraduate Engineering Technology Lean Six Sigma course (4-month period) to design lab safety processes and procedures to reduce the risk of injuries within the engineering lab environments. This case study was designed to incorporate best practice risk-based lab safety approaches to identify potential risks through customer feedback and reduce/mitigate future issues from occurring. Findings: The findings of this study demonstrate the usefulness of applying the Lean Six Sigma DMAIC methodology to identify and mitigate risks based on experienced lab safety personnel. The project demonstrates the importance of communication and customer feedback, and highlights key flaws that should be improved going forward. Originality/Value: This research contributes to the field by demonstrating a case study that combines a Lean Six Sigma focus on incorporating stakeholder requirements for lab safety with the experience of lab safety personnel, in the hopes of designing new risk-based lab safety approaches. Additionally, the study will enhance laboratory practices within higher educational settings and within teaching laboratories.