Purpose: To improve their efficiency and effectiveness, small and medium-sized enterprises (SMEs) are embracing Industry 4.0 (I4.0), which requires new equipment equipped with intelligent control systems. In the light of the new paradigm, it is becoming increasingly important to promote adequate educational provision in the training of Quality Managers (QM). Therefore, by identifying the skills required for QM in the context of SMEs adapting to I4.0, this research aims to help academics understand how curricular units for courses focused on training QM should be designed in this new context. Design/Methodology/Approach: A literature review was conducted, followed by fieldwork that included a focus group session and semi-structured interviews with two distinct groups of companies: (i) those that already had technologies linked to I4.0 or were in the process of implementing them, and (ii) those that develop equipment with the technologies needed to implement the attributes of I4.0. The research was carried out in the north-central region of Portugal. Findings: Results indicate that the profile of the QM is characterized by the strengthening of skills: (i) analytical, with a special focus on knowledge of statistical tools and critical thinking; (ii) leadership and communication, with a focus on the ability to motivate and involve people; and (iii) knowledge of the I4.0 tools to be able to implement a quality management system 4.0. Practical Implications/Limitations: The research highlights the importance of academic-industry partnerships in bridging the gap between education and employment needs. The primary constraints of this study consist of the fact that the interviews were conducted with SMEs in the process of transitioning to I4.0, the potential subjectivity of their opinions, and the limited geographical scope. Originality/Value: This research highlights the importance of incorporating curricular units that promote the development of soft skills alongside technical skills for the complete training of managers. Furthermore, it helps to align training programs with emerging job vacancies, providing companies with professionals capable of facing new challenges and ensuring the collaboration of academia to facilitate this transition and help plan future work needs.