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Also known as the Friedländer condensation, it combines an α-amino aldehyde or ketone with another aldehyde or ketone with at least one methylene α adjacent to the carbonyl to furnish a substituted quinoline. The reaction can be promoted by either acid, base, or heat.

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Friedländer Quinoline Synthesis

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  • 发表日期：

    2026年

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  • Jie Jack Li

摘要

Also known as the Friedländer condensation, it combines an α-amino aldehyde or ketone with another aldehyde or ketone with at least one methylene α adjacent to the carbonyl to furnish a substituted quinoline. The reaction can be promoted by either acid, base, or heat.