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Doebner–von Miller reaction is a variant of the Skraup quinoline synthesis. Therefore, the mechanism for the Skraup reaction is also operative for the Doebner–von Miller reaction. The following mechanism is favored by Denmark’s mechnistic study using 13C-labelled α,β-unsaturated ketones.9

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Doebner–von Miller reaction

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  • 发表日期：

    2026年

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  • Jie Jack Li

摘要

Doebner–von Miller reaction is a variant of the Skraup quinoline synthesis. Therefore, the mechanism for the Skraup reaction is also operative for the Doebner–von Miller reaction. The following mechanism is favored by Denmark’s mechnistic study using 13C-labelled α,β-unsaturated ketones.9