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Treatment of 2-methylpyridine N-oxide with trifluoroacetic anhydride, or acetic anhydride gives rise to the rearrangement product, 2-hydroxymethylpyridine. Also known as the Boekelheide rearrangement.

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Boekelheide Reaction

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  • 发表日期：

    2026年

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  • Jie Jack Li

摘要

Treatment of 2-methylpyridine N-oxide with trifluoroacetic anhydride, or acetic anhydride gives rise to the rearrangement product, 2-hydroxymethylpyridine. Also known as the Boekelheide rearrangement.