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Also known as Biginelli pyrimidone synthesis. One-pot condensation of an aromatic aldehyde, urea, and β-dicarbonyl compound in acidic ethanolic solution and expansion of such a condensation thereof. It belongs to a class of transformations called multicomponent reactions (MCRs).

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Biginelli Reaction

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  • 发表日期：

    2026年

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  • Jie Jack Li

摘要

Also known as Biginelli pyrimidone synthesis. One-pot condensation of an aromatic aldehyde, urea, and β-dicarbonyl compound in acidic ethanolic solution and expansion of such a condensation thereof. It belongs to a class of transformations called multicomponent reactions (MCRs).