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Thiophene synthesis from reaction of 1,4-dicarbonyl compounds with phosphorus pentasulfide (P2S5). The reaction now is frequently carried out using Lawesson’s reagent. For the mechanism of carbonyl to thiocarbonyl transformation, see Lawesson’s reagent.

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Paal–Knorr Thiophene Synthesis

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  • 发表日期：

    2026年

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  • Jie Jack Li

摘要

Thiophene synthesis from reaction of 1,4-dicarbonyl compounds with phosphorus pentasulfide (P2S5). The reaction now is frequently carried out using Lawesson’s reagent. For the mechanism of carbonyl to thiocarbonyl transformation, see Lawesson’s reagent.