This chapter presents a meta-ethnographic synthesis of four studies that describe hope-based interventions used in the South African context to empower youth and equip them with the skills necessary to earn a sustainable livelihood. The integrated approach of the intervention combines the constructs of Hope (Scioli & Biller, 2009, 2010) with the constructs of the CASEL (Collaborative for Academic, Social and Emotional Learning) framework, within a sustainable livelihoods framework (Chambers & Conway,1992) within a sustainable livelihoods framework [Chambers & Conway (Sustainable rural livelihoods: Practical concepts for the 21st century. Institute of Development Studies, 1992)]. The synthesis reveals that culturally relevant, multi-faceted interventions yield positive outcomes for participants, fostering hope and developing critical SEL skills. Key findings highlight the importance of contextually appropriate narratives, the adaptability of interventions to suit participants’ needs, and the effectiveness of a holistic approach addressing multiple domains of participants’ lives. The Hope for a Sustainable Livelihood Intervention, developed and piloted in South Africa, offers a promising model for supporting youth in their transition from education to the workplace by prioritizing contextual relevance and flexibility.