Cutaneous wounds in systemic disorders pose significant challenges for physicians in terms of diagnosis and treatment. Different pathogenic causes with characteristic clinical picture needs a special tailored therapeutic approach. Chronic relapsing ulcerative wounds, including those related to venous insufficiency, neuropathy, and diabetes, account for 85% of cases. The remaining 15% are atypical wounds linked to various systemic conditions as granulomatosis with polyangiitis, Martorell leg ulcer, chronic prurigo, necrobiosis lipoidica, factitial skin ulcers to name only a few. All wounds benefit from modern dressings adapted to the wound bed and the systemic diagnosis. A multidisciplinary approach is necessary for establishing the diagnosis and optimal systemic treatment. The training requirements for systemic wounds address diagnostic and therapeutic measures and are highlighted by the European Training Requirements (ETR) of Wound Healing Multiple Joint Committee (MJC) of the European Union of Medical Specialists (UEMS).