Cross-Modality Image Quality Prediction for Time-Resolved CT from Breathing Signals
摘要
Four-dimensional computed tomography (4DCT) is a time-resolved, multi-modal imaging method that captures respiratory signals synchronised with the CT scan in order to track the movement of the lung. It is routinely used in radiation therapy treatment planning for lung or liver cancer patients. However, image artifacts during 4DCT scans caused by irregular patient breathing negatively impact treatment outcomes. This work proposes a method to automatically detect patients at high risk for severe image artifacts even before the scan is conducted based on an pre-scan analysis of their breathing. This can help to take proactive measures to improve image quality, such as changing the scan mode or providing in-depth patient coaching. A deep neural network is trained to predict the image quality score of 28 lung CT phantom scans, each rated by ten clinical experts. Different pretrained networks are investigated for feature generation and combined with two linear output heads to predict the average expert image quality score of unseen scans. We were able to predict the quality of a 4DCT with a mean absolute error of 8% using only the one-dimensional breathing signal as input. This accuracy is comparable to the rating consistency of our clinical experts, which were rating the images directly.