The management of gastroesophageal reflux disease is a complex process which requires understanding of the treatment strategies which range from lifestyle modifications to surgical interventions. Endoluminal therapies provide an alternative for patients who prefer not to undergo antireflux surgery. Among endoluminal procedures, transoral incisionless fundoplication (TIF) stands out and should be used only on carefully selected patients. This book chapter provides a comprehensive overview of the available devices for TIF, including the EsophyX® device and MUSE™ device, along with their respective published data.