Human talent, ethics, competencies, and commitment are at the core of the safety and value creation that NDE processes provide to our world which impact comprise our infrastructure, transportation equipment, installations, facilities, habitable spaces, and even many everyday objects whose safety and value are intrinsically connected to a human perspective of NDE. In parallel, constraints in knowledge, skills, acquired experience, ethical behavior, or motivation impair safety and the value of NDE is able to create. In the dawn of NDE 4.0, training and work force reorientation play a central role in shaping the professional path of new talent, provide stability, develop opportunities for active practitioners, and contribute to preserve and transmit the accumulated knowledge of experienced generations of NDE practitioners. Industry 4.0 is compelling to revise the roles of NDE practitioners, trainers, and mentors which are immersed not only in the dynamics of exponentially accelerated technological advancements but also in profound social, environmental, and cultural transformations. NDE itself is transitioning from a niche role as quality control support instrument to an invaluable knowledge generating process for creating value through substantial improvements in business sustainability, quality, and safety. This profound transformation is shaping how Education 4.0 for Industry 4.0 will deliver disruptive modifications in education models, training processes, certification schemes, and support tools. We aim that the reader, either within the personal perspective of the practitioner or from the institutional perspective of companies, academic institutions, or training platforms, will find here not only significant strategic frameworks but also practical insights that can contribute to potentialize NDE as a profession toward the future in benefit of all.