In challenging environments, maintaining effective infection prevention and control (IPC) measures is critical. The quality of available supplies often suffers due to substandard manufacturing, improper storage, or reliance on local markets. Addressing these supply chain disruptions and tailoring IPC strategies to local contexts, requires robust collaboration. Healthcare providers, humanitarian organizations, and local authorities must work together to develop and implement effective IPC guidelines. This cooperation ensures that IPC efforts are sustained, even in the most difficult circumstances, by leveraging the strengths and resources of each stakeholder to overcome obstacles and enhance healthcare outcomes.