Infection control, the practical discipline of preventing infections acquired in healthcare settings, is an essential process for every healthcare organization. The role of nurses in prevention has evolved significantly over the years, primarily in response to changes in healthcare demands and practices. In the 1800s, the first nurse, Florence Nightingale, who applied a new organizational method of hygiene in therapeutic environments, observed a significant decrease in mortality rates. She was among the first to understand the importance of epidemiology and medical statistics in interpreting information about the evolution of diseases and the effectiveness of treatments. Since Nightingale’s time, the role of Infection Prevention and Control (IPC) nurses has evolved significantly across many countries. In some healthcare settings, clinical staff with additional IPC training are referred to as “Link Nurses,” serving as liaisons between the IPC team and their clinical areas. These individuals are recognized for their interest in infection control and their leadership at the local level, acting as key contacts for implementing IPC practices. They actively foster relationships between their specialist team and those working in the local clinical environment (such as wards, departments, care homes) and undertake specific tasks or roles within their sphere of responsibility. Recognized by colleagues for their unique function and contribution, and with support from their managers, they have the potential to enhance patient safety strategies by disseminating knowledge and best practices in healthcare settings.