All forms of diabetes are characterized by hyperglycemia and macro- and microangiopathy, which in turn lead to several complications, that is, nephropathy, cardiomyopathy, retinopathy, neuropathy, and loss of red blood cell (RBC) deformability. Also, the fatty acid elongase and desaturase activities are known to decrease diabetes. The present review tries to summarize the link between omega-3 fatty acids and diabetic complications. Thus, reports in the literature suggest that supplementation with omega-3 fatty acid, especially eicosapentaenoic acid (EPA, 20:5, n-3), showed beneficial effects in diabetic nephropathy by improving the renal function in humans as well as in experimental animal studies. Docosahexaenoic acid (DHA) plays a major role in signaling cascades and rhodopsin regeneration, while insufficiency of DHA is associated with impairment of retinal function; supplementation with DHA improves retinal function. While omega-3 polyunsaturated fatty acids (PUFAs) offered protection against cardiovascular diseases, omega-6 PUFAs also showed cardioprotective action. Supplementation with omega-3 fatty acids improved nerve conduction velocity (NCV) and Na+, K+-ATPase activity in diabetic neuropathy. Omega-3 fatty acids increased RBC deformability and decreased plasma viscosity, thereby helping in improving cardiomyopathy associated with RBC deformability.