A novel real-time compact system for ECG and bioimpedance acquisition without complex signal processing algorithms is presented. The device combines a recently developed versatile miniASIC with commercial low-cost Ag/AgCl ECG electrodes. The miniASIC is a custom high-programmable low-power electronic interface for different sensor types. Experimental tests were conducted on a prototype to assess its capability of measuring and preprocessing biomedical signals. The performances of the proposed system were validated with commercial device as benchmark. Experimental results demonstrate that the proposed system is suitable for the implementation of low-cost, portable biomedical devices for healthcare applications.