One of the most urgent global issues, climate change, has long-term effects on countries’ sustainable development. It affects everything from rising sea levels and catastrophic flooding to changing weather patterns that threaten food security. Even though they do not bear the same responsibility as nations in the global north, nations like Botswana are susceptible to effects of climate change. The purpose of this work is to critically examine key challenges and opportunities of climate change literacy in Botswana. This chapter followed a qualitative research design and relies on extensive review of journal articles and official documents in Botswana about climate change literacy. Our work presented emerging findings such as lack of climate change literacy in school curriculum, lack of professional development for educators and lack of resources to teach environmental education. We recommend an employment of local and indigenous knowledge into climate change literacy to build on the rich experiential wisdom passed down by our ancestors.