This chapter provides an introductory guide to initiating research in Artificial Intelligence (AI) in dentistry. It explores AI’s potential transformative role in scientific discoveries, helps formulate targeted research queries, and discusses essential measures in dental AI research, for example, how to read and plan dental AI studies and draft and publish research protocols or papers along existing reporting guidelines. This chapter underscores the pivotal role of data and ethics in creating trustworthy AI dental applications while highlighting the primary challenges in AI research and development and the potential of AI to reduce healthcare costs and expand population coverage. With practical insights and real-world examples, this guide is invaluable for anyone embarking on the fascinating journey into AI in dental research.