Physical activity (PA) is a promoter of health in general. Its benefits include maintaining proper weight, providing stress relief, increasing muscle strength, improving balance and coordination, increasing bone strength, and increasing mental focus. In addition, PA improves the evolution of diseases such as hypertension, diabetes, osteoporosis, and dementia. We can infer that PA is more than a lifestyle; it constitutes a form of therapy in itself. The aim of this chapter is to analyse the impact of healthy PA during peri- and postmenopause, to determine the PA-associated improvements in the symptoms and processes that emerge during this period, and to identify the optimal PA recommendations for those purposes.