While we all agree that we need to provide high-quality care, we cannot be sure of what we are doing unless we measure what we do. Measuring processes and outcomes gives us a sense of knowing where we are compared to where we want to be. The preceding chapters in this book have defined the scope and different angles of understanding, engaging, and supporting families in the ICU. If we want to improve understanding and management of the Family Intensive Care Unit Syndrome (FICUS), we must know how to develop and answer meaningful research questions. In this chapter, we will look at some general aspects of successful clinical research and how these might reflect on the study of FICUS.